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The decline in sod expression might indicate a weakened ability to counteract oxidative damage

The inhibition of pathogenic microorganisms and antigens is produced by the action of gastric, pancreatic, and bile secretions

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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)